{"id":1208,"date":"2026-09-19T11:55:54","date_gmt":"2026-09-19T11:55:54","guid":{"rendered":"https:\/\/bdbpeptides.com\/?post_type=product&p=1208"},"modified":"2026-09-19T11:55:54","modified_gmt":"2026-09-19T11:55:54","slug":"foxo4-dri-10mg-10-vial-kit-senolytic-peptide-senescence-research","status":"publish","type":"product","link":"https:\/\/bdbpeptides.com\/product\/foxo4-dri-10mg-10-vial-kit-senolytic-peptide-senescence-research\/","title":{"rendered":"FOXO4-DRI 10mg | 10-Vial Kit | Senolytic Peptide | Senescence Research"},"content":{"rendered":"

What is FOXO4-DRI??<\/h3>\n

FOXO4-DRI (also called FOXO4-D-Retro-Inverso or FOXO4 p53-Interaction Domain Peptide) is a D-retro-inverso stapled peptide designed to antagonise the interaction between FOXO4 and p53 in senescent cells. In non-senescent cells, p53 localises to mitochondria to trigger apoptosis when activated. In senescent cells, FOXO4 sequesters p53 in the nucleus, suppressing this apoptotic programme and enabling senescent cell survival (SASP). FOXO4-DRI disrupts this FOXO4\u2013p53 interaction, restoring nuclear p53 export \u2192 mitochondrial translocation \u2192 apoptosis selectively in senescent cells \u2014 without affecting normal proliferating cells.<\/p>\n","protected":false},"excerpt":{"rendered":"

FOXO4-DRI (D-Retro-Inverso FOXO4 senolytic peptide) \u2014 \u226599% HPLC purity, MS confirmed, Janoshik COA. Research use only.<\/p>\n","protected":false},"featured_media":1209,"comment_status":"open","ping_status":"closed","template":"","meta":[],"iconvert-abtest-template":[],"product_brand":[],"product_cat":[27],"product_tag":[],"class_list":["post-1208","product","type-product","status-publish","has-post-thumbnail","product_cat-peptides","first","instock","shipping-taxable","purchasable","product-type-simple"],"yoast_head":"\nFOXO4-DRI 10mg | 10-Vial Kit | Senolytic Peptide | Senescence Research - Baohua Dongnuo Biotechnology<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/bdbpeptides.com\/product\/foxo4-dri-10mg-10-vial-kit-senolytic-peptide-senescence-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FOXO4-DRI 10mg | 10-Vial Kit | Senolytic Peptide | Senescence Research - Baohua Dongnuo Biotechnology\" \/>\n<meta property=\"og:description\" content=\"FOXO4-DRI (D-Retro-Inverso FOXO4 senolytic peptide) \u2014 \u226599% HPLC purity, MS confirmed, Janoshik COA. 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