PNC-27 5mg | 10-Vial Kit | Anticancer Peptide Kit

PNC-27 5mg | 10-Vial Kit | Anticancer Peptide Kit

$240.00

PNC-27 5mg | 10-Vial Kit — p53-derived proapoptotic peptide — penetrates HDM-2-overexpressing cancer cell membranes to trigger membranolytic apoptosis selectively in tumour cells that overexpress HDM-2. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.

Category: Peptides

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What is PNC-27?

PNC-27 (HDM2-targeting chimeric anticancer peptide) is a 32-amino acid chimeric peptide (HDM2-binding + penetratin). Chimeric peptide combining an HDM2 (human double minute 2)-binding domain with a penetratin cell-penetrating sequence. Proposed mechanism: binds membrane-associated HDM2 overexpressed on cancer cell surfaces, disrupting p53-HDM2 interaction and inducing selective cancer cell membranolysis while sparing normal cells.