PEG MGF 2mg | 10-Vial Kit | Pegylated Mechano Growth Factor | Long-Acting Muscle Repair Research

Description

What is PEG-MGF??

PEG-MGF (Pegylated Mechano Growth Factor, CAS 88096-37-7) is the polyethylene glycol-conjugated form of native MGF (IGF-1 Ec splice variant). Molecular formula C121H200N42O39, MW ~2888 g/mol (core peptide). PEGylation extends the half-life from ~5-7 minutes (native MGF) to 48-72 hours, enabling systemic distribution and sustained satellite cell activation. PEG-MGF activates muscle stem cells via the IGF-1R/PI3K/Akt/mTOR axis, drives MyoD and myogenin gene expression, and stimulates myofiber regeneration and hypertrophy in preclinical models. Unlike native MGF’s highly localised short-lived paracrine action, PEG-MGF’s sustained circulation enables whole-body satellite cell activation from a single administration.