Gonadorelin 5mg | 10-Vial Kit | GnRH Decapeptide | HPG Axis & Gonadotropin Research

Description

What is Gonadorelin??

Gonadorelin (CAS 33515-09-2) is the synthetic form of endogenous gonadotropin-releasing hormone (GnRH / LHRH) — a 10-amino acid hypothalamic decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂). Molecular formula C₅₅H₇₅N₁₇O₁₃, MW 1182.31 g/mol. Released in pulses from hypothalamic GnRH neurons, it binds the GnRHR (Gq/PLC/IP₃) on anterior pituitary gonadotrophs — stimulating LH and FSH synthesis and secretion. Pulsatile gonadorelin activates the HPG axis; continuous administration causes receptor downregulation and gonadotropin suppression — making it the definitive tool for studying pulse-dependent HPG axis regulation.