Description
What is Tirzepatide?
Tirzepatide (Dual GIP+GLP-1 receptor agonist) is a 39-amino acid dual-modified synthetic peptide. First approved dual GIP and GLP-1 receptor co-agonist — one molecule activating both incretin receptors simultaneously. GIPR co-agonism adds: adipose lipolysis, thermogenesis, and hypothalamic GLP-1R sensitisation. SURMOUNT-5 (2025): 20.2% vs 13.7% mean weight reduction vs semaglutide 2.4mg at 72 weeks. SURPASS-2: superior HbA1c vs semaglutide 1mg.
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