ACE-031 1mg | 10-Vial Kit | Myostatin Inhibitor | ActRIIB-Fc Fusion Protein Research

Description

What is ACE-031??

ACE-031 (also known as Ramatercept, CAS 1621169-52-5) is a recombinant fusion protein composed of the extracellular ligand-binding domain of activin receptor type IIB (ACVR2B) linked to the Fc region of human IgG1. It functions as a soluble decoy receptor, sequestering myostatin (GDF-8), activin A, activin B, GDF-11, and BMP-9 in circulation — preventing these negative regulators from binding membrane-bound ACVR2B on muscle and bone cells. Developed by Acceleron Pharma, ACE-031 has a half-life of approximately 10–15 days in human pharmacokinetic studies.