Description
What is MOTS-c?
MOTS-c (Mitochondria-derived peptide (mitochondrial 12S rRNA-encoded)) is a 16-amino acid mitochondria-encoded peptide. Mitochondria-derived peptide encoded by the 12S rRNA gene — translocates to the nucleus under metabolic stress to regulate AMPK and folate-methionine cycle activity. Declines with age. Extends lifespan in aged male mice, improves insulin sensitivity, exercise capacity, and thermogenic response to cold stress.








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