Description
What is Semaglutide?
Semaglutide (GLP-1 receptor agonist (94% homology to native GLP-1)) is a 31-amino acid fatty acid-conjugated peptide. Selective GLP-1 receptor agonist with 94% amino acid homology to native GLP-1, fatty acid conjugation enabling weekly dosing. Activates GLP-1R on pancreatic beta cells, hypothalamus, heart, and kidney — glucose-dependent insulin secretion, appetite suppression, gastric emptying delay, and direct cardiovascular effects. SELECT CVOT (2023): 20% MACE reduction.
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