Description
What is Cagrilintide?
Cagrilintide (Long-acting amylin receptor agonist (CALCR/RAMP)) is a Amylin analog (fatty acid-conjugated for weekly dosing). Long-acting amylin analog activating the amylin receptor complex (calcitonin receptor CALCR + receptor activity-modifying proteins RAMP1/2/3) via brainstem area postrema and hypothalamic circuits — appetite suppression pathway distinct from GLP-1R. Weekly dosing; combined with semaglutide in CagriSema Phase 3.
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